Orient House is a building located in Jerusalem that served as the headquarters of the Palestine Liberation Organization (PLO) in the 1980s and 1990s.

The Palestine Liberation Organization is a Palestinian nationalist coalition that is internationally recognized as the official representative of the Palestinian people. Founded in 1964, it initially sought to establish an Arab state over the entire territory of the former Mandatory Palestine, advocating the elimination of the State of Israel. However, in 1993, the PLO recognized Israeli sovereignty with the Oslo I Accord, and now only seeks Arab statehood in the Palestinian territories that have been militarily occupied by Israel since the 1967 Arab–Israeli War.