The Ormskirk branch line is a railway line in Lancashire, England, running between Preston and Ormskirk. The train service is operated by Northern Trains, who usually operate class 150, 156, and 158 units. The line is the northern section of the former Liverpool, Ormskirk and Preston Railway; the line from Ormskirk to Liverpool is now part of Merseyrail's Northern Line. Prior to the introduction of the 1970–71 London Midland Region timetable, it was a secondary main line from Liverpool to Scotland, Blackpool, and Yorkshire. From 4 May 1970, however, the line was severed at Ormskirk. With express trains eliminated, stopping services at the village stations en route were improved, and have retained a similar frequency to this day.

Merseyrail is a commuter rail network which serves Merseyside and adjacent areas of Cheshire and Lancashire. Merseyrail serves 69 stations, 67 of which it manages, across two lines – the Northern Line and the Wirral Line. The network uses 750 V DC third rail electrified lines having 75.0 miles (120.7 km) of routes, of which 6.5 miles (10.5 km) are underground. Since January 2023, Merseyrail commenced replacing its train fleet, withdrawing the Class 507 and 508 trains and introducing 53 new Class 777 trains. The network carried 25.5 million passengers in the 2022/2023 statistical period.