Ornithine decarboxylase
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The enzyme ornithine decarboxylase catalyzes the decarboxylation of ornithine to form putrescine. Ornithine is part of both the urea cycle and polyamine synthesis, and this reaction is the committed s
Ornithine decarboxylase dimer, Human
In molecular biology, Ornithine decarboxylase antizyme is an ornithine decarboxylase inhibitor. It binds to, and destabilises, ornithine decarboxylase, a key enzyme in polyamine synthesis. ODC is then
Ornithine decarboxylase
…they are bound and degraded by the proteasome, ODC degradation is instead mediated by several recognition sites on the protein and its accessory factor antizyme. The ODC degradation process is regulated in a negative feedback loop by its reaction products. Until a report by Sheaff et al. (2000), which demonstrated…
NMR structure of antizyme isoform 1 from rat