Osceola, named Billy Powell at birth in Alabama, became an influential leader of the Seminole people in Florida. His mother was Muscogee, and his great-grandfather was a Scotsman, James McQueen. He was reared by his mother in the Creek (Muscogee) tradition. When he was a child, they migrated to Florida with other Red Stick refugees, led by a relative, Peter McQueen, after their group's defeat in 1814 in the Creek Wars. There they became part of what was known as the Seminole people.

The Seminole are a Native American people who developed in Florida in the 18th century. Today, they live in Oklahoma and Florida, and comprise three federally recognized tribes: the Seminole Nation of Oklahoma, the Seminole Tribe of Florida, and the Miccosukee Tribe of Indians of Florida, as well as independent groups. The Seminole people emerged in a process of ethnogenesis from various Native American groups who settled in Spanish Florida beginning in the early 1700s, most significantly northern Muscogee Creeks from what are now Georgia and Alabama.