The Osthofen concentration camp was an early Nazi concentration camp in Osthofen, close to Worms, Germany. It was established in March 1933 in a former paper factory. The camp was administered by the People's State of Hesse's Political Police, with guards first drawn from SA and SS, later only SS men. The first prisoners were mostly Communists or Social Democrats, but later Jehovah's Witnesses, Seventh-Day Adventists and non-political Jews were also sent to the camp.

Osthofen is a town in the middle of the Wonnegau in the Alzey-Worms district in Rhineland-Palatinate, Germany. Since 1 July 2014 it is part of the Verbandsgemeinde Wonnegau. Osthofen was raised to town on 24 October 1970.