Otoe County is a county in the U.S. state of Nebraska. As of the 2020 United States Census, the population was 15,912. Its county seat is Nebraska City. The county was formed in 1854, and was named tor the Otoe Indian tribe.

Nebraska City is a city in Nebraska and the county seat of Otoe County, Nebraska, United States. As of the 2020 census, the city population was 7,222.