Oxford is a city in Calhoun, Talladega, and Cleburne counties in the State of Alabama, United States. The population was 22,069 at the 2020 census,. Oxford is one of two principal cities of and included in the Anniston-Oxford Metropolitan Statistical Area, and it is the largest city in Calhoun County by population.

Calhoun County is a county in the east central part of the U.S. state of Alabama. As of the 2020 census, the population was 116,441. Its county seat is Anniston. It is named in honor of John C. Calhoun, a US Senator from South Carolina.