Painkiller Jane is a fictional superheroine created by Jimmy Palmiotti and Joe Quesada for Event Comics in 1995. Originally a five-issue mini-series, the character went on to star in numerous crossover titles with the likes of the Punisher, Vampirella, and Hellboy.

James Palmiotti is an American writer and inker of comic books, who also does writing for games, television and film.