Palacio de los López, officially titled Palacio de Gobierno is a neoclassical manor in Asunción, Paraguay, that serves as a workplace for the President of Paraguay, and is also the seat of the government of Paraguay. The president does not reside in the palace, and is instead housed at Mburuvicha Róga, some 2.5 km to the southeast.

Asunción is the capital and the largest city of Paraguay. The city stands on the eastern bank of the Paraguay River, almost at the confluence of this river with the Pilcomayo River. The Paraguay River and the Bay of Asunción in the northwest separate the city from the Occidental Region of Paraguay and from Argentina in the south part of the city. The rest of the city is surrounded by the Central Department.