Panjwayi is a district in Kandahar Province, Afghanistan. It is located about 35 kilometres (22 mi) west of Kandahar. The district borders Helmand Province to the southwest, Maywand District to the west, Zhari District to the north, Arghandab, Kandahar and Daman districts to the east and Reg District to the south. Panjwayi was reduced in size in 2004 when Zhari District was created out of the northern part of it, on the northern side of the Arghandab River, which now forms the northern boundary.

Kandahār is one of the thirty-four provinces of Afghanistan, located in the southern part of the country, sharing a border with Pakistan, to the south. It is surrounded by Helmand in the west, Uruzgan in the north and Zabul Province in the east. Its capital is the city of Kandahar, Afghanistan's second largest city, which is located on the Arghandab River. The greater region surrounding the province is called Loy Kandahar. The Emir of Afghanistan sends orders to Kabul from Kandahar making it the de facto capital of Afghanistan, although the main government body operates in Kabul. All meetings with the Emir take place in Kandahar, meetings excluding the Emir are in Kabul.