Parkside railway station was an original station on the Liverpool and Manchester Railway. It then became the interchange station between lines when the Wigan Branch Railway opened in 1832, moving to the physical junction of the two lines in 1838. The station continued as an interchange until being by-passed in 1847 when a west curve was opened to facilitate north–south links that did not go through the station. Traffic declined further after the Winwick cut-off opened in 1864 leading to closure in 1878.

The Liverpool and Manchester Railway (L&MR) was the first inter-city railway in the world. It opened on 15 September 1830 between the Lancashire towns of Liverpool and Manchester in England. It was also the first railway to rely exclusively on locomotives driven by steam power, with no horse-drawn traffic permitted at any time; the first to be entirely double track throughout its length; the first to have a true signalling system; the first to be fully timetabled; and the first to carry mail.