Pawhuska is a city in and the county seat of Osage County, Oklahoma, United States. As of the 2020 census, the population of the city was 2,984. It was named after the 19th-century Osage chief, Paw-Hiu-Skah, which means "White Hair" in English. The Osage tribal government, which opened offices in Pawhuska in 1872 when its reservation was established in Indian Territory, continues to be based in Pawhuska.

Osage County is the largest county by area in the U.S. state of Oklahoma. Created in 1907 when Oklahoma was admitted as a state, the county is named for and is home to the federally recognized Osage Nation. The county is coextensive with the Osage Nation Reservation, established by treaty in the 19th century when the Osage relocated there from Kansas. The county seat is in Pawhuska, one of the first three towns established in the county. The total population of the county as of 2020 was 45,818.