Pearsall is a city in and the county seat of Frio County, Texas, United States. The population was 7,325 at the 2020 census, down from 9,146 at the 2010 census.

Frio County is a county located in the U.S. state of Texas. As of the 2020 census, its population was 18,385. The county seat is Pearsall. The county was created in 1858 and later organized in 1871. Frio is named for the Frio River, whose name is Spanish for "cold".