Pennsylvania Route 144 is a state highway located in the U.S. state of Pennsylvania, covering a distance of about 109 miles (175 km). The southern terminus is located near an interchange with U.S. Route 322 (US 322) at State Route 2015 in Potter Township while the northern terminus is located at US 6 in Galeton. Between Snow Shoe and Renovo, PA 144 is known as the High Plateau Scenic Byway, a Pennsylvania Scenic Byway.

U.S. Route 322 is a spur of US 22, running from Cleveland, Ohio, east to Atlantic City, New Jersey. In the U.S. state of Pennsylvania, the route runs from the Ohio state line in West Shenango Township southeast to the Commodore Barry Bridge over the Delaware River in Chester, at which point the route crosses into New Jersey, meeting the New Jersey Turnpike at exit 2. The route passes near or through several cities, including Meadville, DuBois, State College, and Harrisburg. US 322 in Pennsylvania is named the 28th Division Highway in honor of the 28th Infantry Division.