Pennsylvania Route 147 is a north–south route that runs for 58.3 miles (93.8 km) along the east shore of the Susquehanna River in central Pennsylvania, United States. The southern terminus is at an interchange with U.S. Route 22 /US 322 in Reed Township. The northern terminus is at an interchange with Interstate 80 (I-80) and I-180 in Turbot Township.

U.S. Route 22 (US 22) is an east–west United States Numbered Highway that stretches from Cincinnati, Ohio, in the west, to Newark, New Jersey, in the east. In Pennsylvania, the route runs for 338.20 miles (544.28 km) between the West Virginia state line in Washington County, where it is a freeway through the western suburbs of Pittsburgh, and then runs east to Easton and the Pennsylvania–New Jersey state line in the Lehigh Valley region of eastern Pennsylvania.