Pennsylvania Route 61 is an 81.8-mile-long (131.6 km) state highway that is located in Pennsylvania in the United States. The route is signed on a north–south direction, running from U.S. Route 222 Business in Reading northwest to US 11/US 15/PA 147 in Shamokin Dam.

U.S. Route 11 (US 11) roughly parallels Interstate 81 (I-81) in the U.S. state of Pennsylvania. The route runs from the Maryland state line in Antrim Township, Franklin County, northeast to the New York state line in Great Bend Township, Susquehanna County. US 11 serves Harrisburg, Wilkes-Barre, and Scranton. Between Harrisburg and Scranton, US 11 follows the Susquehanna River, while I-81 follows a shorter route over the mountains further to the east.