Pennsylvania Route 408 is a 24.2-mile-long (38.9 km) state highway located in Crawford County, Pennsylvania. The western terminus is at US 6/US 19/PA 86 in Cambridge Springs. The eastern terminus is at PA 8 in Hydetown.

Crawford County is a county in the Commonwealth of Pennsylvania. As of the 2020 census, the population was 83,938. Its county seat is Meadville. The county was created on March 12, 1800, from part of Allegheny County and named for Colonel William Crawford. The county is part of the Northwest Pennsylvania region of the state.