Pennsylvania Route 435 (PA 435) is a 14.9-mile-long (24.0 km) state highway located in Monroe, Wayne, and Lackawanna counties in Pennsylvania. The southern terminus is at Interstate 380 (I-380) near Gouldsboro. The northern terminus is at I-84 and I-380 in Dunmore. The route heads north from I-380 and the southern terminus of PA 507 in Monroe County as a four-lane road, passing through a small section of Wayne County before entering Lackawanna County. PA 435 becomes a two-lane road at the PA 307 junction and continues north to intersect PA 502 in Daleville and PA 690 in Moscow. After intersecting PA 590, the route becomes a four-lane divided highway and intersects PA 348 before merging into I-84/I-380.

Wayne is a county in the Commonwealth of Pennsylvania. The county's population was 51,155 at the 2020 census. The county seat is the Borough of Honesdale. The county was formed from part of Northampton County on March 21, 1798, and was named for the Revolutionary War General Anthony Wayne. The county is part of the Northeast Pennsylvania region of the state.