Pennsylvania Route 456 is a 12.1-mile-long (19.5 km) state highway located in Franklin County, Pennsylvania. The southern terminus is at the Maryland state line near Yeakle's Mill Bridge, where it continues as Hollow Road. The northern terminus is at PA 16 near Cove Gap. The route is a two-lane undivided road called Little Cove Road that passes through a narrow agricultural valley in southwestern Franklin County. PA 456 was designated in 1937 onto its current alignment.

Franklin County is a county in the Commonwealth of Pennsylvania. As of the 2020 census, the population was 155,932. Its county seat is Chambersburg.