Pennsylvania Route 68 is a 90.036-mile-long (144.899 km) east–west state highway located in western Pennsylvania in the United States. The western terminus of the route is at the Ohio state line west of Glasgow, where PA 68 continues into Ohio as State Route 39. The eastern terminus is at U.S. Route 322 in Clarion. The route runs southwest-northeast across Beaver, Butler, Armstrong, and Clarion counties. PA 68 follows the Ohio River between the Ohio border and Beaver, where it crosses the Beaver River into Rochester and heads northeast away from the Ohio River. The route runs through rural areas to Butler County, where it intersects Interstate 79 (I-79) in Zelienople before serving Evans City and Butler. PA 68 passes through a section of Armstrong County before crossing the Allegheny River into Clarion County. Here, the route passes through Rimersburg and Sligo before it has an interchange with I-80 and continues to its terminus in Clarion.

State Route 39 is a primarily east–west running state highway in north-central and northeastern portion of the U.S. state of Ohio. The route runs through seven counties on its approximately 155-mile (249 km) trip through the region. Its western terminus is at State Route 103 near New Washington, and its eastern terminus is at PA 68 near East Liverpool.