Pennsylvania Route 73 (PA 73) is a 62.32-mile (100.29 km) long east–west state highway in southeastern Pennsylvania. It runs from PA 61 near Leesport southeast to the New Jersey state line on the Tacony–Palmyra Bridge over the Delaware River in Philadelphia, where the road continues south as New Jersey Route 73. The route passes through rural areas of Berks County, crossing U.S. Route 222 (US 222) in Maiden Creek before heading southeast through Oley and Boyertown. PA 73 continues into Montgomery County and intersects PA 100 in Gilbertsville and PA 29 in Schwenksville before it heads into the northwest suburbs of Philadelphia. The route passes through Skippack and intersects US 202 in Center Square, PA 309 in Springfield Township, and PA 611 near Jenkintown. PA 73 continues through Northeast Philadelphia on Cottman Avenue, crossing US 1 and US 13 before coming to an interchange with Interstate 95 (I-95) near the Tacony–Palmyra Bridge.

U.S. Route 222 is a U.S. Highway that is a spur of US 22 in the states of Maryland and Pennsylvania. It runs for 95 miles (153 km) from US 1 in Conowingo, Maryland, north to the junction of Interstate 78 (I-78) and Pennsylvania Route 309 in Dorneyville, Pennsylvania. US 222 is almost entirely in Pennsylvania, and serves as the state's principal artery between the Lancaster and Reading areas in the west and the Lehigh Valley in the east.