Piedmont is a city in Calhoun and Cherokee counties in the U.S. state of Alabama. The population was 4,400 at the 2020 census. It is included in the Anniston-Oxford, Alabama Metropolitan Statistical Area.

Calhoun County is a county in the east central part of the U.S. state of Alabama. As of the 2020 census, the population was 116,441. Its county seat is Anniston. It is named in honor of John C. Calhoun, a US Senator from South Carolina.