Pine Bluffs is a town in eastern Laramie County, Wyoming, United States. It is located on the county's border with Nebraska. Pine Bluffs is part of the Cheyenne, Wyoming, Metropolitan Statistical Area. The population was 1,129 at the 2010 census. It was first known as Rock Ranch, but the name was changed by railroad officials for the pines on the nearby bluffs.

Laramie County is a county located at the southeast corner of the state of Wyoming. As of the 2020 United States Census, the population was 100,512 or 17.4% of the state's total 2020 population, making it the most populous county in Wyoming, but the least populous county in the United States to be the most populous in its state.