Pioneer 2 was the last of the three project Able space probes designed to probe lunar and cislunar space. The launch took place at 07:30:21 GMT on 8 November 1958. After Pioneer 1 had failed due to guidance system deficiencies, the guidance system was modified with a Doppler command system to ensure more accurate commands and minimize trajectory errors. Once again, the first and second stage portion of the flight was uneventful, but the third stage of the launch vehicle failed to ignite, making it impossible for Pioneer 2 to achieve orbital velocity. An attempt to fire the vernier engines on the probe was unsuccessful and the spacecraft attained a maximum altitude of 1,550 km (960 mi) before reentering Earth's atmosphere at 28.7° N, 1.9° E over NW Africa. A small amount of data was obtained during the short flight, including evidence that the equatorial region around Earth has higher flux and higher energy radiation than previously considered and that the micrometeorite density is higher around Earth than in space. The reason for the third stage failure was unclear, but it was suspected that the firing command from the second stage, which contained the guidance package for the entire launch vehicle, was never received, possibly due to damage to electrical lines during staging.

The Pioneer programs were two series of United States lunar and planetary space probes exploration. The first program, which ran from 1958 to 1960, unsuccessfully attempted to send spacecraft to orbit the Moon, successfully sent one spacecraft to fly by the Moon, and successfully sent one spacecraft to investigate interplanetary space between the orbits of Earth and Venus. The second program, which ran from 1965 to 1992, sent four spacecraft to measure interplanetary space weather, two to explore Jupiter and Saturn, and two to explore Venus. The two outer planet probes, Pioneer 10 and Pioneer 11, became the first two of five artificial objects to achieve the escape velocity that will allow them to leave the Solar System, and carried a golden plaque each depicting a man and a woman and information about the origin and the creators of the probes, in case any extraterrestrials find them someday.