Pioneer 4 was an American spin-stabilized uncrewed spacecraft launched as part of the Pioneer program on a lunar flyby trajectory and into a heliocentric orbit making it the first probe of the United States to escape from the Earth's gravity. Launched on March 3, 1959, it carried a payload similar to Pioneer 3: a lunar radiation environment experiment using a Geiger–Müller tube detector and a lunar photography experiment. It passed within 58,983 km (36,650 mi) of the Moon's surface. However, Pioneer 4 did not come close enough to trigger its photoelectric sensor. The spacecraft was still in solar orbit as of 1969. It was the only successful lunar probe launched by the U.S. in 12 attempts between 1958 and 1963; only in 1964 would Ranger 7 surpass its success by accomplishing all of its mission objectives.

The Pioneer programs were two series of United States lunar and planetary space probes exploration. The first program, which ran from 1958 to 1960, unsuccessfully attempted to send spacecraft to orbit the Moon, successfully sent one spacecraft to fly by the Moon, and successfully sent one spacecraft to investigate interplanetary space between the orbits of Earth and Venus. The second program, which ran from 1965 to 1992, sent four spacecraft to measure interplanetary space weather, two to explore Jupiter and Saturn, and two to explore Venus. The two outer planet probes, Pioneer 10 and Pioneer 11, became the first two of five artificial objects to achieve the escape velocity that will allow them to leave the Solar System, and carried a golden plaque each depicting a man and a woman and information about the origin and the creators of the probes, in case any extraterrestrials find them someday.