The Piromalli 'ndrina is one of the most powerful clans of the 'Ndrangheta, a criminal and mafia-type organisation in Calabria, Italy. The 'ndrina is based in Gioia Tauro on the Tyrrhenian coast. The Piromalli's are allied with their relatives of the Molè family, also from Gioia Tauro. Often they are referred to as the Piromalli-Molè clan. The Piromalli clan contains more than 200 members.

The 'Ndrangheta is an Italian Mafia-type association based in the peninsular region of Calabria and dating back to the 19th century. Although loosely structured, it is considered one of the most powerful organized crime groups in the world. It is characterized by a horizontal structure made up of autonomous clans known as 'ndrine, based almost exclusively on blood ties. Since the 1950s, following wide-scale emigration from Calabria, 'Ndrangheta clans dispersed to other European countries, Australia and the Americas. Currently, its main activity is drug trafficking, but it also deals with arms trafficking, money laundering, racketeering, extortion, and loan sharking.