Plakoglobin
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Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. Plakoglobin is a member of the catenin protein family and homologous to β-cate
Simplified scheme of cell junctions. TJ, Tight junctions; AJ, Adherens junctions; D, Desmosomes; ZO, Zonula occludens; PG, Plakoglobin, PKP, Plakophilin; DP, Desmoplakin
Adenomatous polyposis coli
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Adenomatous polyposis coli also known as deleted in polyposis 2.5 is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrati
Plakoglobin
…degradation. Phosphorylation of N-terminal Serines by a “destruction complex” composed of glycogen synthase kinase 3β (GSK3β) and scaffold proteins adenomatous polyposis coli (APC) and axin targets plakoglobin for degradation.[31–33]. The phosphorylated motif is recognized by β-TrCP, a ubiquitin ligase that targets plakoglobin…
PBB Protein APC image
Familial adenomatous polyposis of the intestine
1deb: CRYSTAL STRUCTURE OF THE N-TERMINAL COILED COIL DOMAIN FROM APC
1m5i: Crystal Structure of the coiled coil region 129-250 of the tumor suppressor gene product APC