Play the Blues: Live from Jazz at Lincoln Center is a 2011 live album by Eric Clapton and Wynton Marsalis. Released on September 13, it contains live recordings of the 2011 collaboration at the Lincoln Center for the Performing Arts between the British blues guitarist and the American jazz trumpeter. A video release accompanies the audio recordings. The live album reached various national charts and was certified in several territories.

Wynton Learson Marsalis is an American trumpeter, composer, and music instructor, who is currently the artistic director of Jazz at Lincoln Center. He has been active in promoting classical and jazz music, often to young audiences. Marsalis has won nine Grammy Awards, and his oratorio Blood on the Fields was the first jazz composition to win the Pulitzer Prize for Music. Marsalis is the only musician to have won a Grammy Award in both jazz and classical categories in the same year.