Pocomoke City, dubbed "the friendliest town on the Eastern Shore", is a city in Worcester County, Maryland, United States. Although renamed in a burst of civic enthusiasm in 1878, the city is regularly referred to by its inhabitants simply as Pocomoke. The population was 4,184 at the 2010 census. It is part of the Salisbury, Maryland-Delaware Metropolitan Statistical Area. Pocomoke City is a center for commerce on the lower shore, home to an industrial park currently playing host to defense contractors, aerospace engineering, and plastics fabrication. Pocomoke City is located near the Wallops Island Flight Facility in Wallops Island, Virginia.

Worcester County is the easternmost county of the U.S. state of Maryland. As of the 2020 census, the population was 52,460. Its county seat is Snow Hill.