Mutilation was a common method of punishment for criminals in the Byzantine Empire, but it also had a role in the empire's political life. By blinding a rival, one would not only restrict his mobility but also make it almost impossible for him to lead an army into battle, then an important part of taking control of the empire. Castration was also used to eliminate potential opponents. In the Byzantine Empire, for a man to be castrated meant that he was no longer a man—half-dead, "life that was half death". Castration also eliminated any chance of heirs being born to threaten either the emperor's or the emperor's children's place at the throne. Other mutilations were the severing of the nose (rhinotomy), or the amputating of limbs.

Justinian II, nicknamed "the Slit-Nosed", was the last Byzantine emperor of the Heraclian dynasty, reigning from 685 to 695 and again from 705 to 711. Like his namesake, Justinian I, Justinian II was an ambitious and passionate ruler who was keen to restore the Roman Empire to its former glories. However, he responded brutally to any opposition to his will and lacked the finesse of his father, Constantine IV. Consequently, he generated enormous opposition to his reign, resulting in his deposition in 695 in a popular uprising. He only returned to the throne in 705 with the help of a Bulgar and Slav army. His second reign was even more despotic than the first, and in 711 he was killed by mutinous soldiers.