Demetrius I, 12th Bishop and Patriarch of Alexandria. Sextus Julius Africanus, who visited Alexandria in the Bishoprice of Demetrius, places his accession as eleventh bishop from Mark in the tenth year of Roman Emperor Commodus; Eusebius of Caesarea places it in the tenth year of Septimus Severus.

Origen of Alexandria, also known as Origen Adamantius, was an early Christian scholar, ascetic, and theologian who was born and spent the first half of his career in Alexandria. He was a prolific writer who wrote roughly 2,000 treatises in multiple branches of theology, including textual criticism, biblical exegesis and hermeneutics, homiletics, and spirituality. He was one of the most influential and controversial figures in early Christian theology, apologetics, and asceticism. He has been described as "the greatest genius the early church ever produced".