Pope John XXII, born Jacques Duèze, was head of the Catholic Church from 7 August 1316 to his death, in December 1334. He was the second and longest-reigning Avignon Pope, elected by the Conclave of Cardinals, which was assembled in Lyon. Like his predecessor, Clement V, Pope John centralized power and income in the Papacy and lived a princely life in Avignon.

The Avignon Papacy was the period from 1309 to 1376 during which seven successive popes resided in Avignon rather than in Rome. The situation arose from the conflict between the papacy and the French crown, culminating in the death of Pope Boniface VIII after his arrest and maltreatment by Philip IV of France. Following the subsequent death of Pope Benedict XI, Philip forced a deadlocked conclave to elect the French Clement V as pope in 1305. Clement refused to move to Rome, and in 1309 he moved his court to the papal enclave at Avignon, where it remained for the next 67 years. This absence from Rome is sometimes referred to as the "Babylonian captivity of the Papacy".