Pope Sylvester I was the bishop of Rome from 31 January 314 until his death on 31 December 335. He filled the See of Rome at an important era in the history of the Western Church, though very little is known of his life.

Constantine I, also known as Constantine the Great, was a Roman emperor from AD 306 to 337 and the first Roman emperor to convert to Christianity. He played a pivotal role in elevating the status of Christianity in Rome, decriminalizing Christian practice and ceasing Christian persecution in a period referred to as the Constantinian shift. This initiated the cessation of the established ancient Roman religion. Constantine is also the originator of the religiopolitical ideology known as Constantinism, which epitomizes the unity of church and state, as opposed to separation of church and state. He founded the city of Constantinople and made it the capital of the Empire, which remained so for over a millenium.