The Portland class of heavy cruisers was a class of ships designed and constructed by the United States Navy in 1930. The two ships of the class, Portland and Indianapolis, saw extensive service during the Pacific War in World War II.

A heavy cruiser was a type of cruiser, a naval warship designed for long range and high speed, armed generally with naval guns of roughly 203 mm (8 inches) in calibre, whose design parameters were dictated by the Washington Naval Treaty of 1922 and the London Naval Treaty of 1930. Heavy cruisers were generally larger, more heavily-armed and more heavily-armoured than light cruisers while being smaller, faster, and more lightly-armed and armoured than battlecruisers and battleships. Heavy cruisers were assigned a variety of roles ranging from commerce raiding to serving as 'cruiser-killers,' i.e. hunting and destroying similarly-sized ships