Portlaoise railway station is a station on the Dublin to Cork/Limerick lines in Ireland. It is also the terminus for the South Western Commuter also called the Portlaoise Commuter Line which forms part of the Dublin Suburban Rail network in the commuter belt for Dublin. It is the busiest county town railway station in the midlands region with up to 32 trains to Dublin and 30 trains from Dublin per day.

The Dublin–Cork Main Line is the main InterCity railway route in Ireland between Dublin Heuston and Cork Kent. In 2018, 3.46 million passengers travelled on the line, a 10% increase from 2017 figures.