1.
Cotton swab
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Cotton swabs or cotton buds consist of a small wad of cotton wrapped around one or both ends of a short rod, usually made of either wood, rolled paper, or plastic. They are commonly used in a variety of applications including first aid, cosmetics application, cleaning, the cotton swab is a tool invented in the 1920s by Leo Gerstenzang after he attached wads of cotton to toothpicks. His product, which he named Baby Gays, went on to become the most widely sold brand name, Q-tips, the term Q-tips is often used as a genericized trademark for cotton swabs in the USA and Canada. The Q-tips brand is owned by Unilever and had over $200 million in sales in the US in 2014, although doctors have said for years that usage of the cotton swab for ear cleaning or scratching is not safe, such use remains the most common. The traditional cotton swab has a tip on a wooden handle. They are usually long, about six inches. These often are packaged sterile, one or two to a paper or plastic sleeve, the advantage of the paper sleeve and the wooden handle is that the package can be autoclaved to be sterilized. Cotton swabs manufactured for use are usually shorter, about three inches long, and usually double-tipped. The handles were first made of wood, then made of rolled paper and they are often sold in large quantities,100 or more to a container. Plastic swab stems exist in a variety of colors, such as blue. However, the cotton itself is traditionally white, the most common use for cotton swabs is to clean or caress the ear canal and/or to remove earwax, despite this not being a medically recommended method for removing earwax. Cotton swabs are commonly used for applying and removing makeup, as well as for household uses such as cleaning. Medical-type swabs are used to take microbiological cultures. They are swabbed onto or into the area, then wiped across the culture medium, such as an agar plate. They are also used to take DNA samples, most commonly by scraping cells from the cheek in the case of humans. They can be used to apply medicines to an area, to selectively remove substances from a targeted area. They are also used as an applicator for various cosmetics, ointments, a related area is the use of swabs for microbiological environmental monitoring. Once taken, the swab can be streaked onto an agar plate, the broth can either then be filtered or incubated and examined for microbial growth
2.
Drug nomenclature
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Drug nomenclature is the systematic naming of drugs, especially pharmaceutical drugs. Generic names for drugs are nowadays constructed out of affixes and stems that classify the drugs into different categories, a marketed drug might also have a company code or compound code. The chemical names are the names, based on the molecular structure of the drug. There are various systems of nomenclature and thus various chemical names for any one substance. The most important is the IUPAC name, chemical names are typically very long and too complex to be commonly used in referring to a drug. Sometimes, a company that is developing a drug might give the drug a company code, for example, CDP870 is UCB’s company code for Cimzia. Many of these codes, although not all, have prefixes that correspond to the company name, during development, the company will apply for regulatory approval of the drug by the relevant national regulatory agency, and it will apply for a generic name for that country. It will also apply for an International Nonproprietary Name through the World Health Organization, nowadays the national nonproprietary names are usually the same as the INN. The generic names usually indicate via their stems what drug class the drug belongs to, for example, one can tell that aciclovir is an antiviral drug because its name ends in the -vir suffix. Otherwise the 2 names are both given, joined by hyphens or slashes. For example, suspensions combining trimethoprim and sulfamethoxazole are called either trimethoprim/sulfamethoxazole or co-trimoxazole, similarly, co-codamol is codeine-acetaminophen, and co-triamterzide is triamterene-hydrochlorothiazide. The USP ceased maintaining PENs, but the similar co-prefixed BANs are still current, for drugs that make it all the way through development, testing, and regulatory acceptance, the pharmaceutical company then gives the drug a trade name. The term trade name is a term in the pharmaceutical industry for a brand name or trademark name. For example, Lipitor is Pfizers trade name for atorvastatin, a cholesterol-lowering medication, Drug names are often subject to legal regulation, including approval for new drugs and on packaging to establish clear rules about adulterants and fraudulent or misleading labelling. A national formulary is often designated to define drug names for regulatory purposes, unbiased mentions of a drug place the nonproprietary name first and follow it with the trade name in parentheses, if relevant. This pattern is important for the literature, where conflict of interest is disclosed or avoided. The authors reporting on a study are not endorsing any particular brand of drug and they will often state which brand was used, for methodologic validity, but they do so in a way that makes clear the absence of endorsement. For example, the 2015 American Society of Hematology publication policies say, Non-proprietary names should be used and he first letter of the name of a proprietary drug should be capitalized
3.
Drugs.com
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Drugs. com is an online pharmaceutical encyclopedia which provides drug information for consumers and healthcare professionals primarily in the USA. The domain Drugs. com was registered by Bonnie Neubeck in 1994. In 1999 at the height of the boom, Eric MacIver purchased an option to buy the domain from Neubeck. com. Venture Frogs sold the drugs. com domain name to an investor in June 2001. The Drugs. com website is owned and operated by the Drugsite Trust, the Drugsite Trust is a privately held Trust administered by two New Zealand pharmacists, Karen Ann and Phillip James Thornton The Drugs. com website was officially launched in September 2001. Stedmans, AHFS, Harvard Health Publications, Mayoclinic, North American Compendiums, in March 2008, Drugs. com announced the release of Mednotes —an online personal medication record application which connected to Google Health. In May 2010, U. S. FDA announced a collaboration with Drugs. com to distribute consumer health updates on the Drugs. com website, Drugs. com is certified by the TRUSTe online privacy certification program and the HONcode Health on the Net Foundation
4.
Regulation of therapeutic goods
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The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. In some countries, such as the United States, they are regulated at the level by a single agency. In other jurisdictions they are regulated at the level, or at both state and national levels by various bodies, as is the case in Australia. The role of therapeutic goods regulation is designed mainly to protect the health, regulation is aimed at ensuring the safety, quality, and efficacy of the therapeutic goods which are covered under the scope of the regulation. In most jurisdictions, therapeutic goods must be registered before they are allowed to be marketed, there is usually some degree of restriction of the availability of certain therapeutic goods depending on their risk to consumers. Therapeutic goods in Australia are regulated by the Therapeutic Goods Administration, there are 5 main categories, Normal Medicines - Cough, cold and fever medicines, antiseptics, vitamins and others. Sold freely in pharmacies and some large supermarkets, red Stripe Medicines - These medicines are sold only with medical prescription. Antibiotics, Anti allergenics, Anti inflammatories, and other medicines, in Brazil, governmental control is loose on this type, it is not uncommon to buy this type of prescription medicine over the counter without a prescription. Red Stripe Psychoactive Medicines - These medicines are only with a Special Control white medical prescription with carbon copy. The original must be retained by the pharmacist after the sale, Drugs include anti-depressants, anti-convulsants, some sleep aids, anti-psychotics and other non-habit-inducing controlled medicines. Though some consider them habit inducing, anabolic steroids are also regulated under this category, black Stripe Medicines - These medicines are sold only with the Blue B Form medical prescription, which is valid for 30 days and must be retained by the pharmacist after the sale. Includes sedatives, some anorexic inducers and other habit-inducing controlled medicines, includes amphetamines and other stimulants, opioids and other strong habit-forming controlled medicines. In Canada, regulation of goods are governed by the Food and Drug Act. In addition, the Controlled Drugs and Substances Act requires additional regulatory requirements for controlled drugs, the regulation of drugs in Burma is governed by the Food and Drug Administration and Food and Drug Board of Authority. The regulation of drugs in China is governed by the China Food, Medicines for Human Use in the United Kingdom are regulated by the Medicines and Healthcare products Regulatory Agency. The availability of drugs is regulated by classification by the MHRA as part of marketing authorisation of a product, Medicines in the Republic of Ireland are regulated according to the Misuse of Drugs Regulations 1988. Controlled drugs are divided into five categories based on their potential for misuse, cD1, cannabis, lysergamide, coca leaf, etc. Use prohibited except in limited circumstances where a license has been granted, CD2, amphetamine, methadone, morphine, fentanyl, oxycodone, tapentadol, etc
5.
Over-the-counter drug
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In many countries, OTC drugs are selected by a regulatory agency to ensure that they are ingredients that are safe and effective when used without a physicians care. OTC drugs are regulated by active pharmaceutical ingredients, not final products. By regulating APIs instead of specific drug formulations, governments allow manufacturers freedom to formulate ingredients, or combinations of ingredients, into proprietary mixtures. The term over-the-counter may be somewhat counterintuitive, since, in many countries, in contrast, prescription drugs are almost always passed over a counter from the pharmacist to the customer. Some drugs may be classified as over-the-counter, but may only be dispensed by a pharmacist after an assessment of the patients needs or the provision of patient education. In many countries, a number of OTC drugs are available in establishments without a pharmacy, such as stores, supermarkets. Regulations detailing the establishments where drugs may be sold, who is authorized to dispense them, as of 2011, around a third of older adults in the U. S. reportedly use OTC drugs. In Canada, there are four drug schedules, Schedule 1, Schedule 2, Do not require a prescription, but require an assessment by a pharmacist prior to sale. These drugs are kept in an area of the pharmacy where there is no public access, Schedule 3, Do not require a prescription, but must be kept in an area under the supervision of a pharmacist. These drugs are kept in an area of the outlet where self-selection is possible. Unscheduled, Do not require a prescription and may be sold in any retail outlet, all medications outside of Schedule 1 may be considered an OTC drug, as they do not require prescriptions for sale. While the National Association of Pharmacy Regulatory Authorities provides recommendations on the scheduling of drugs for sale in Canada, due to this, the exact drugs found in each schedule may vary from province to province. The drug can be on the shelves like any other product, examples are domperidone,400 mg ibuprofen up to 50 tablets and dextromethorphan. The drugs are usually on the shelves and the store sells items like toys, gadgets, perfumes. The drugs in this category have limited risk and addiction potential, examples are naproxen and diclofenac in small amounts, cinnarizine,400 mg ibuprofen up to 20 tablets and also 500 mg paracetamol up to 50 tablets. In the United States, the manufacture and sale of OTC substances is regulated by the Food, the FDA requires that all new drugs obtain a New Drug Application before entering interstate commerce, but the act exempts any drugs generally recognized as safe and effective from this requirement. Thus, in the United States an OTC drug product is allowed to be marketed either pursuant to an FDA monograph, the Federal Trade Commission regulates advertising of OTC products. This is in contrast to prescription drug advertising, which is regulated by the FDA, the FDA requires that OTC products are labeled with an approved Drug Facts label to educate consumers about their medications
6.
PubChem
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PubChem is a database of chemical molecules and their activities against biological assays. The system is maintained by the National Center for Biotechnology Information, a component of the National Library of Medicine, PubChem can be accessed for free through a web user interface. Millions of compound structures and descriptive datasets can be downloaded via FTP. PubChem contains substance descriptions and small molecules with fewer than 1000 atoms and 1000 bonds, more than 80 database vendors contribute to the growing PubChem database. PubChem consists of three dynamically growing primary databases, as of 28 January 2016, Compounds,82.6 million entries, contains pure and characterized chemical compounds. Substances,198 million entries, contains also mixtures, extracts, complexes, bioAssay, bioactivity results from 1.1 million high-throughput screening programs with several million values. PubChem contains its own online molecule editor with SMILES/SMARTS and InChI support that allows the import and export of all common chemical file formats to search for structures and fragments. In the text search form the database fields can be searched by adding the name in square brackets to the search term. A numeric range is represented by two separated by a colon. The search terms and field names are case-insensitive, parentheses and the logical operators AND, OR, and NOT can be used. AND is assumed if no operator is used, example,0,5000,50,10 -5,5 PubChem was released in 2004. The American Chemical Society has raised concerns about the publicly supported PubChem database and they have a strong interest in the issue since the Chemical Abstracts Service generates a large percentage of the societys revenue. To advocate their position against the PubChem database, ACS has actively lobbied the US Congress, soon after PubChems creation, the American Chemical Society lobbied U. S. Congress to restrict the operation of PubChem, which they asserted competes with their Chemical Abstracts Service
7.
ChemSpider
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ChemSpider is a database of chemicals. ChemSpider is owned by the Royal Society of Chemistry, the database contains information on more than 50 million molecules from over 500 data sources including, Each chemical is given a unique identifier, which forms part of a corresponding URL. This is an approach to develop an online chemistry database. The search can be used to widen or restrict already found results, structure searching on mobile devices can be done using free apps for iOS and for the Android. The ChemSpider database has been used in combination with text mining as the basis of document markup. The result is a system between chemistry documents and information look-up via ChemSpider into over 150 data sources. ChemSpider was acquired by the Royal Society of Chemistry in May,2009, prior to the acquisition by RSC, ChemSpider was controlled by a private corporation, ChemZoo Inc. The system was first launched in March 2007 in a release form. ChemSpider has expanded the generic support of a database to include support of the Wikipedia chemical structure collection via their WiChempedia implementation. A number of services are available online. SyntheticPages is an interactive database of synthetic chemistry procedures operated by the Royal Society of Chemistry. Users submit synthetic procedures which they have conducted themselves for publication on the site and these procedures may be original works, but they are more often based on literature reactions. Citations to the published procedure are made where appropriate. They are checked by an editor before posting. The pages do not undergo formal peer-review like a journal article. The comments are moderated by scientific editors. The intention is to collect practical experience of how to conduct useful chemical synthesis in the lab, while experimental methods published in an ordinary academic journal are listed formally and concisely, the procedures in ChemSpider SyntheticPages are given with more practical detail. Comments by submitters are included as well, other publications with comparable amounts of detail include Organic Syntheses and Inorganic Syntheses
8.
ChEMBL
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ChEMBL or ChEMBLdb is a manually curated chemical database of bioactive molecules with drug-like properties. It is maintained by the European Bioinformatics Institute, of the European Molecular Biology Laboratory, based at the Wellcome Trust Genome Campus, Hinxton, the database, originally known as StARlite, was developed by a biotechnology company called Inpharmatica Ltd. later acquired by Galapagos NV. The data was acquired for EMBL in 2008 with an award from The Wellcome Trust, resulting in the creation of the ChEMBL chemogenomics group at EMBL-EBI, the ChEMBL database contains compound bioactivity data against drug targets. Bioactivity is reported in Ki, Kd, IC50, and EC50, data can be filtered and analyzed to develop compound screening libraries for lead identification during drug discovery. ChEMBL version 2 was launched in January 2010, including 2.4 million bioassay measurements covering 622,824 compounds and this was obtained from curating over 34,000 publications across twelve medicinal chemistry journals. ChEMBLs coverage of available bioactivity data has grown to become the most comprehensive ever seen in a public database, in October 2010 ChEMBL version 8 was launched, with over 2.97 million bioassay measurements covering 636,269 compounds. ChEMBL_10 saw the addition of the PubChem confirmatory assays, in order to integrate data that is comparable to the type, ChEMBLdb can be accessed via a web interface or downloaded by File Transfer Protocol. It is formatted in a manner amenable to computerized data mining, ChEMBL is also integrated into other large-scale chemistry resources, including PubChem and the ChemSpider system of the Royal Society of Chemistry. In addition to the database, the ChEMBL group have developed tools and these include Kinase SARfari, an integrated chemogenomics workbench focussed on kinases. The system incorporates and links sequence, structure, compounds and screening data, the primary purpose of ChEMBL-NTD is to provide a freely accessible and permanent archive and distribution centre for deposited data. July 2012 saw the release of a new data service, sponsored by the Medicines for Malaria Venture. The data in this service includes compounds from the Malaria Box screening set, myChEMBL, the ChEMBL virtual machine, was released in October 2013 to allow users to access a complete and free, easy-to-install cheminformatics infrastructure. In December 2013, the operations of the SureChem patent informatics database were transferred to EMBL-EBI, in a portmanteau, SureChem was renamed SureChEMBL. 2014 saw the introduction of the new resource ADME SARfari - a tool for predicting and comparing cross-species ADME targets
9.
European Chemicals Agency
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ECHA is the driving force among regulatory authorities in implementing the EUs chemicals legislation. ECHA helps companies to comply with the legislation, advances the safe use of chemicals, provides information on chemicals and it is located in Helsinki, Finland. The Agency, headed by Executive Director Geert Dancet, started working on 1 June 2007, the REACH Regulation requires companies to provide information on the hazards, risks and safe use of chemical substances that they manufacture or import. Companies register this information with ECHA and it is freely available on their website. So far, thousands of the most hazardous and the most commonly used substances have been registered, the information is technical but gives detail on the impact of each chemical on people and the environment. This also gives European consumers the right to ask whether the goods they buy contain dangerous substances. The Classification, Labelling and Packaging Regulation introduces a globally harmonised system for classifying and labelling chemicals into the EU. This worldwide system makes it easier for workers and consumers to know the effects of chemicals, companies need to notify ECHA of the classification and labelling of their chemicals. So far, ECHA has received over 5 million notifications for more than 100000 substances, the information is freely available on their website. Consumers can check chemicals in the products they use, Biocidal products include, for example, insect repellents and disinfectants used in hospitals. The Biocidal Products Regulation ensures that there is information about these products so that consumers can use them safely. ECHA is responsible for implementing the regulation, the law on Prior Informed Consent sets guidelines for the export and import of hazardous chemicals. Through this mechanism, countries due to hazardous chemicals are informed in advance and have the possibility of rejecting their import. Substances that may have effects on human health and the environment are identified as Substances of Very High Concern 1. These are mainly substances which cause cancer, mutation or are toxic to reproduction as well as substances which persist in the body or the environment, other substances considered as SVHCs include, for example, endocrine disrupting chemicals. Companies manufacturing or importing articles containing these substances in a concentration above 0 and they are required to inform users about the presence of the substance and therefore how to use it safely. Consumers have the right to ask the retailer whether these substances are present in the products they buy, once a substance has been officially identified in the EU as being of very high concern, it will be added to a list. This list is available on ECHA’s website and shows consumers and industry which chemicals are identified as SVHCs, Substances placed on the Candidate List can then move to another list
10.
Chemical formula
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These are limited to a single typographic line of symbols, which may include subscripts and superscripts. A chemical formula is not a name, and it contains no words. Although a chemical formula may imply certain simple chemical structures, it is not the same as a full chemical structural formula. Chemical formulas can fully specify the structure of only the simplest of molecules and chemical substances, the simplest types of chemical formulas are called empirical formulas, which use letters and numbers indicating the numerical proportions of atoms of each type. Molecular formulas indicate the numbers of each type of atom in a molecule. For example, the formula for glucose is CH2O, while its molecular formula is C6H12O6. This is possible if the relevant bonding is easy to show in one dimension, an example is the condensed molecular/chemical formula for ethanol, which is CH3-CH2-OH or CH3CH2OH. For reasons of structural complexity, there is no condensed chemical formula that specifies glucose, chemical formulas may be used in chemical equations to describe chemical reactions and other chemical transformations, such as the dissolving of ionic compounds into solution. A chemical formula identifies each constituent element by its chemical symbol, in empirical formulas, these proportions begin with a key element and then assign numbers of atoms of the other elements in the compound, as ratios to the key element. For molecular compounds, these numbers can all be expressed as whole numbers. For example, the formula of ethanol may be written C2H6O because the molecules of ethanol all contain two carbon atoms, six hydrogen atoms, and one oxygen atom. Some types of compounds, however, cannot be written with entirely whole-number empirical formulas. An example is boron carbide, whose formula of CBn is a variable non-whole number ratio with n ranging from over 4 to more than 6.5. When the chemical compound of the consists of simple molecules. These types of formulas are known as molecular formulas and condensed formulas. A molecular formula enumerates the number of atoms to reflect those in the molecule, so that the formula for glucose is C6H12O6 rather than the glucose empirical formula. However, except for very simple substances, molecular chemical formulas lack needed structural information, for simple molecules, a condensed formula is a type of chemical formula that may fully imply a correct structural formula. For example, ethanol may be represented by the chemical formula CH3CH2OH
11.
Antiseptic
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Antiseptic are antimicrobial substances that are applied to living tissue/skin to reduce the possibility of infection, sepsis, or putrefaction. Disinfectants do not kill bacterial spores e. g. on surgical instruments, even sterilization may not destroy prions. Some antibiotics are true germicides, capable of destroying microbes, while others are bacteriostatic, antibacterials are antiseptics that have the proven ability to act against bacteria. Microbicides which destroy virus particles are called viricides or antivirals, antisepsis was recommended by Hungarian physician Ignaz Semmelweis in 1847 but, tragically, he was ignored. In this paper, Lister advocated the use of acid as a method of ensuring that any germs present were killed. Some of this work was anticipated by, Ancient Greek physicians Galen and Hippocrates and their theories were bitterly opposed by Galenist Guy de Chauliac and others trained in the classical tradition. Joseph Smith alluded to the use of alcohol as an antiseptic in February 1833, specifically, verse 7 states, And, again, strong drinks are not for the belly, but for the washing of your bodies. More commonly, 3% solutions of hydrogen peroxide have been used in household first aid for scrapes, however, the strong oxidization causes scar formation and increases healing time during fetal development. Iodine is usually used in a solution or as Lugols iodine solution as a pre-. Some people do not recommend disinfecting minor wounds with iodine because of concern that it may induce scar tissue formation, however, concentrations of 1% iodine or less have not been shown to increase healing time and are not otherwise distinguishable from treatment with saline. Polyhexanide is a compound suitable for clinical use in critically colonized or infected acute. The physicochemical action on the bacterial envelope prevents or impedes the development of resistant bacterial strains, balsam of Peru is a mild antiseptic. By continued exposure to antibiotics, bacteria may evolve to the point where they are no longer harmed by these compounds, bacteria can also develop a resistance to antiseptics, but the effect is generally less pronounced. The mechanism by which bacteria evolve may vary in response to different antiseptics, low concentrations of an antiseptic may encourage growth of a bacterial strain that is resistant to the antiseptic, where a higher concentration of the antiseptic would simply kill the bacteria. In addition, use of a high concentration of an antiseptic may cause tissue damage or slow the process of wound healing
12.
Surgery
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An act of performing surgery may be called a surgical procedure, operation, or simply surgery. In this context, the verb means to perform surgery. The adjective surgical means pertaining to surgery, e. g. surgical instruments or surgical nurse, the patient or subject on which the surgery is performed can be a person or an animal. A surgeon is a person who practices surgery and an assistant is a person who practices surgical assistance. A surgical team is made up of surgeon, surgeons assistant, anesthesia provider, circulating nurse, Surgery usually spans minutes to hours, but it is typically not an ongoing or periodic type of treatment. The term surgery can also refer to the place where surgery is performed, or simply the office of a physician, dentist, Surgery is a technology consisting of a physical intervention on tissues. As a general rule, a procedure is considered surgical when it involves cutting of a patients tissues or closure of a previously sustained wound, surgical procedures are commonly categorized by urgency, type of procedure, body system involved, degree of invasiveness, and special instrumentation. Based on timing, Elective surgery is done to correct a condition, and is carried out at the patients request, subject to the surgeons. A semi-elective surgery is one that must be done to avoid permanent disability or death, emergency surgery is surgery which must be done promptly to save life, limb, or functional capacity. Based on purpose, Exploratory surgery is performed to aid or confirm a diagnosis, therapeutic surgery treats a previously diagnosed condition. Cosmetic surgery is done to improve the appearance of an otherwise normal structure. By type of procedure, Amputation involves cutting off a part, usually a limb or digit. Resection is the removal of all or part of an organ or part of the body. Replantation involves reattaching a severed body part, reconstructive surgery involves reconstruction of an injured, mutilated, or deformed part of the body. Excision is the cutting out or removal of an organ, tissue, transplant surgery is the replacement of an organ or body part by insertion of another from different human into the patient. Removing an organ or body part from a human or animal for use in transplant is also a type of surgery. By body part, When surgery is performed on one system or structure. Examples include cardiac surgery, gastrointestinal surgery, and orthopedic surgery, by contrast, an open surgical procedure such as a laparotomy requires a large incision to access the area of interest
13.
Complex (chemistry)
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Many metal-containing compounds, especially those of transition metals, are coordination complexes. A coordination complex whose centre is an atom is called a metal complex. Coordination complexes are so pervasive that their structures and reactions are described in many ways, the atom within a ligand that is bonded to the central metal atom or ion is called the donor atom. In a typical complex, an ion is bonded to several donor atoms. A polydentate ligand is a molecule or ion that bonds to the atom through several of the ligands atoms. These complexes are called chelate complexes, the formation of complexes is called chelation, complexation. The central atom or ion, together with all ligands comprise the coordination sphere, the central atoms or ion and the donor atoms comprise the first coordination sphere. Coordination refers to the covalent bonds between the ligands and the central atom. Originally, a complex implied a reversible association of molecules, atoms, as applied to coordination chemistry, this meaning has evolved. Some metal complexes are formed virtually irreversibly and many are bound together by bonds that are quite strong, the number of donor atoms attached to the central atom or ion is called the coordination number. The most common coordination numbers are 2,4 and especially 6, for example, the cobalt hexahydrate ion or the hexaaquacobalt ion 2+, is a hydrated-complex ion that consists of six water molecules attached to a metal ion Co. The oxidation state and the number reflect the number of bonds formed between the metal ion and the ligands in the complex ion. However the coordination number of Pt2+ 2is 4 since it has two ligands, which contain four donor atoms in total. Coordination complexes have been known since the beginning of modern chemistry, early well-known coordination complexes include dyes such as Prussian blue. Their properties were first well understood in the late 1800s, following the 1869 work of Christian Wilhelm Blomstrand, Blomstrand developed what has come to be known as the complex ion chain theory. The theory claimed that the reason coordination complexes form is because in solution and he compared this effect to the way that various carbohydrate chains form. Following this theory, Danish scientist Sophus Mads Jorgensen made improvements to it and it was not until 1893 that the most widely accepted version of the theory today was published by Alfred Werner. Werner’s work included two important changes to the Blomstrand theory, the first was that Werner described the two different ion possibilities in terms of location in the coordination sphere
14.
Polyvinylpyrrolidone
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It is used as a binder in many pharmaceutical tablets, it simply passes through the body when taken orally. However, autopsies have found that crospovidone contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption, the long-term effects of crospovidone or povidone within the lung are unknown. PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties and this complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine among a plethora of others, for this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost. Povidone is used as a lubricant in some eye drops, e. g. Bausch & Lombs Soothe and this has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers. PVP is also used in personal care products, such as shampoos and toothpastes, in paints and it has also been used in contact lens solutions and in steel-quenching solutions. PVP is the basis of the formulas for hair sprays and hair gels. As a food additive, PVP is a stabilizer and has E number E1201 and it is also used in the wine industry as a fining agent for white wine or some beers. Other references state that polyvinyl pyrrolidone and its derivatives are fully from mineral synthetic origin, therefore, its use in the production should not be a problem for vegans. In molecular biology, PVP can be used as an agent during Southern blot analysis as a component of Denhardts buffer. It is also good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed, in microscopy, PVP is useful for making an aqueous mounting medium. The U. S. Food and Drug Administration has approved this chemical for many uses, for example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP component of the solution. A woman, who had previously experienced urticaria from various hair products and she was found to be allergic to PVP. In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP, povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, allergies attributed to these other chemicals may possibly be caused by the PVP instead. Broadhurst, JAFC2000 PVP is soluble in water and other polar solvents, for example, it is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea. When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water, in solution, it has excellent wetting properties and readily forms films
15.
Hydrogen iodide
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Hydrogen iodide is a diatomic molecule and hydrogen halide. Aqueous solutions of HI are known as acid or hydriodic acid. Hydrogen iodide and hydroiodic acid are, however, different in that the former is a gas under standard conditions, HI is used in organic and inorganic synthesis as one of the primary sources of iodine and as a reducing agent. HI is a gas that reacts with oxygen to give water. With moist air, HI gives a mist of hydroiodic acid and it is exceptionally soluble in water, giving hydroiodic acid. One liter of water will dissolve 425 liters of HI, the most concentrated solution having only four molecules per molecule of HI. Hydroiodic acid is not pure hydrogen iodide, but a mixture containing it, commercial concentrated hydroiodic acid usually contains 48–57% HI by mass. The solution forms an azeotrope boiling at 127 °C with 57% HI, the high acidity is caused by the dispersal of the ionic charge over the anion. The iodide ion is much larger than the common halides. By contrast, an ion is much smaller, meaning its negative charge is more concentrated. This weaker H+···I− interaction in HI facilitates dissociation of the proton from the anion and is the reason HI is the strongest acid of the hydrohalides, HI can also be distilled from a solution of NaI or other alkali iodide in concentrated phosphoric acid. For many years, this reaction was considered to involve a simple bimolecular reaction between molecules of H2 and I2. However, when a mixture of the gases is irradiated with the wavelength of light equal to the energy of I2, about 578 nm. Like HBr and HCl, HI adds to alkenes, HI + H2C=CH2 → H 3CCH 2I HI is also used in chemistry to convert primary alcohols into alkyl halides. This reaction also occurs for secondary and tertiary alcohols, but substitution occurs via the SN1 pathway, HI can also be used to cleave ethers into alkyl iodides and alcohols, in a reaction similar to the substitution of alcohols. This type of cleavage is significant because it can be used to convert a chemically stable, in this example diethyl ether is split into ethanol and iodoethane, The reaction is regioselective, as iodide tends to attack the less sterically hindered ether carbon. HI is subject to the same Markovnikov and anti-Markovnikov guidelines as HCl, although harsh by modern standards, HI was commonly employed as a reducing agent early on in the history of organic chemistry. Chemists in the 19th century attempted to prepare cyclohexane by HI reduction of benzene at high temperatures, in the case of benzyl alcohols and alcohols with α-carbonyl groups, reduction by HI can provide synthetically useful yields of the corresponding hydrocarbon product
16.
Iodine
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Iodine is a chemical element with symbol I and atomic number 53. The heaviest of the halogens, it exists as a lustrous. The elemental form was discovered by the French chemist Bernard Courtois in 1811 and it was named two years later by Joseph-Louis Gay-Lussac from this property, after the Greek ἰωδης violet-coloured. Iodine occurs in many states, including iodide, iodate. It is the least abundant of the halogens, being the sixty-first most abundant element. It is even less abundant than the rare earths. It is the heaviest essential element, iodine is found in the thyroid hormones. Iodine deficiency affects two billion people and is the leading preventable cause of intellectual disabilities. The dominant producers of today are Chile and Japan. Iodine and its compounds are used in nutrition. Due to its atomic number and ease of attachment to organic compounds. Because of the specificity of its uptake by the human body, iodine is also used as a catalyst in the industrial production of acetic acid and some polymers. In 1811, iodine was discovered by French chemist Bernard Courtois, at that time of the Napoleonic Wars, saltpeter was in great demand in France. Saltpeter produced from French nitre beds required sodium carbonate, which could be isolated from seaweed collected on the coasts of Normandy, to isolate the sodium carbonate, seaweed was burned and the ash washed with water. The remaining waste was destroyed by adding sulfuric acid, Courtois once added excessive sulfuric acid and a cloud of purple vapour rose. He noted that the vapour crystallised on cold surfaces, making dark crystals, Courtois suspected that this material was a new element but lacked funding to pursue it further. Courtois gave samples to his friends, Charles Bernard Desormes and Nicolas Clément and he also gave some of the substance to chemist Joseph Louis Gay-Lussac, and to physicist André-Marie Ampère. On 29 November 1813, Desormes and Clément made Courtois discovery public and they described the substance to a meeting of the Imperial Institute of France
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Microorganism
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A microorganism or microbe is a microscopic organism, which may be single-celled or multicellular. The study of microorganisms is called microbiology, a subject that began with the discovery of microorganisms in 1674 by Antonie van Leeuwenhoek, microorganisms are very diverse and include all bacteria, archaea and most protozoa. This group also contains some fungi, algae, and some such as rotifers. Many macroscopic animals and plants have microscopic juvenile stages, some microbiologists classify viruses and viroids as microorganisms, but others consider these as nonliving. In July 2016, scientists identified a set of 355 genes from the last universal ancestor of all life, including microorganisms. Microorganisms, under certain test conditions, have observed to thrive in the vacuum of outer space. Microorganisms likely far outweigh all other living things combined, the mass of prokaryote microorganisms including the bacteria and archaea may be as much as 0.8 trillion tons of carbon, out of the total biomass of between 1 and 4 trillion tons. Microorganisms appear to thrive in the Mariana Trench, the deepest spot in the Earths oceans, in August 2014, scientists confirmed the existence of microorganisms living 800 m below the ice of Antarctica. According to one researcher, You can find microbes everywhere — theyre extremely adaptable to conditions, microorganisms are crucial to nutrient recycling in ecosystems as they act as decomposers. As some microorganisms can fix nitrogen, they are a part of the nitrogen cycle. Microorganisms are also exploited in biotechnology, both in food and beverage preparation, and in modern technologies based on genetic engineering. A small proportion of microorganisms are pathogenic, causing disease and even death in plants, Robert Hooke coined the term cell after viewing plant cells under his microscope. Antonie Van Leeuwenhoek was one of the first people to observe microorganisms in 1673, later, in the 19th century, Louis Pasteur found that microorganisms caused food spoilage, debunking the theory of spontaneous generation. In 1876 Robert Koch discovered that microorganisms cause diseases, single-celled microorganisms were the first forms of life to develop on Earth, approximately 3–4 billion years ago. Further evolution was slow, and for about 3 billion years in the Precambrian eon, so, for most of the history of life on Earth, the only forms of life were microorganisms. Bacteria, algae and fungi have been identified in amber that is 220 million years old, microorganisms tend to have a relatively fast rate of evolution. Most microorganisms can reproduce rapidly, and bacteria are able to freely exchange genes through conjugation, transformation and transduction. This rapid evolution is important in medicine, as it has led to the development of multidrug resistant pathogenic bacteria, superbugs, the possible existence of microorganisms was discussed for many centuries before their discovery in the 17th century
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Health system
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There is a wide variety of health systems around the world, with as many histories and organizational structures as there are nations. In some countries, health system planning is distributed among market participants, however, health care planning has been described as often evolutionary rather than revolutionary. According to WHO, healthcare systems goals are good health for the citizens, responsiveness to the expectations of the population, progress towards them depends on how systems carry out four vital functions, provision of health care services, resource generation, financing, and stewardship. Other dimensions for the evaluation of systems include quality, efficiency, acceptability. They have also described in the United States as the five Cs, Cost, Coverage, Consistency, Complexity. Also, continuity of care is a major goal. Often health system has been defined with a reductionist perspective, for reducing it to healthcare system. In many publications, for example, both expressions are used interchangeably, the World Health Organization defines health systems as follows, A health system consists of all organizations, people and actions whose primary intent is to promote, restore or maintain health. This includes efforts to influence determinants of health as well as more direct health-improving activities, a health system is therefore more than the pyramid of publicly owned facilities that deliver personal health services. It includes inter-sectoral action by staff, for example, encouraging the ministry of education to promote female education. Healthcare providers are institutions or individuals providing healthcare services and they may also work outside of direct patient care such as in a government health department or other agency, medical laboratory, or health training institution. One study based on data from the OECD concluded that all types of health care finance are compatible with an efficient health system, the study also found no relationship between financing and cost control. The term health insurance is used to describe a form of insurance that pays for medical expenses. It is sometimes used broadly to include insurance covering disability or long-term nursing or custodial care needs. It may be provided through an insurance program, or from private insurance companies. It may be obtained on a basis or purchased by individual consumers. In each case premiums or taxes protect the insured from high or unexpected health care expenses, the benefit is typically administered by a government agency, a non-profit health fund or a corporation operating seeking to make a profit. Many government schemes also have co-payment schemes but exclusions are rare because of political pressure, the larger insurance schemes may also negotiate fees with providers
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Developing world
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Also, the general term less-developed country should not be confused with the specific least developed country. The term developing describes a currently observed situation and not a dynamic or expected direction of progress, since the late 1990s developing countries tended to demonstrate higher growth rates than the developed ones. There is criticism of the use of the developing country. The term implies inferiority of a country or undeveloped country compared with a developed country. It assumes a desire to develop along the traditional Western model of development which a few countries, such as Cuba and Bhutan. An alternative measurement that has suggested is that of gross national happiness. Countries on the boundary between developed and developing are often categorized under the newly industrialized countries. In the 2016 edition of its World Development Indicators, the World Bank made a decision to no longer distinguish between “developed” and “developing” countries in the presentation of its data, nobody has ever agreed on a definition for these terms in the first place. Various terms are used for whatever is not a developed country, terms used include less developed country or less economically developed country, and for the more extreme, least developed country or least economically developed country. But according to the United Nations Statistics Division, There is no established convention for the designation of developed, the World Bank classifies countries into four income groups. These are set each year on July 1, economies were divided according to 2016 GNI per capita using the following ranges of income, Low income countries had GNI per capita of US$1,025 or less. Lower middle income countries had GNI per capita between US$1,026 and US$4,035, upper middle income countries had GNI per capita between US$4,036 and US$12,475. High income countries had GNI per capita above US$12,476 and this may be by absolute numbers or country ranking. The UN has developed the Human Development Index, an indicator of the above statistics. The UN sets Millennium Development Goals from a blueprint developed by all of the countries and leading development institutions. There is an association between low income and high population growth. The terms utilized when discussing developing countries refer to the intent, other terms sometimes used are less developed countries, least economically developed countries, underdeveloped nations or Third World nations, and non-industrialized nations. Conversely, developed countries, most economically developed countries, First World nations and that is, LEDCs are the poorest subset of LDCs
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National Health Service
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The National Health Service is the name of the public health services of England, Scotland and Wales, and is commonly used to refer to those of Northern Ireland. They were established together as one of the social reforms following the Second World War on the founding principles of being comprehensive, universal. Today, each provides a range of health services, the vast majority of which are free for people ordinarily resident in the United Kingdom. Taken together, the four National Health Services in 2015-16 employed around 1.6 million people with a budget of £136.7 billion. For non-residents, the NHS is free at the time of use, for general practitioner, the NHS began on the Appointed Day of 5 July 1948. This put into practice Westminster legislation for England and Wales from 1946 and Scotland from 1947, when Clement Attlees Labour Party won the 1945 election he appointed Aneurin Bevan as Health Minister. Bevan then embarked upon what the historian of the NHS, Charles Webster. Three years after the founding of the NHS, Bevan resigned from the Labour government in opposition to the introduction of charges for the provision of dentures and glasses, the following year, Winston Churchills Conservative government introduced prescription charges. These charges were the first of many controversies over reforms to the NHS throughout its history, each of the UKs four nations have their own separate NHS, each with its own history. From its earliest days, the history of the NHS has shown its place in British society reflected and debated in film, TV, cartoons. However, some functions might be performed by one health service on behalf of another. There have been issues about cross-border payments, taken together, the four National Health Services in 2015-16 employed around 1.6 million people with a combined budget of £136.7 billion. In 2014 the total health sector workforce across the UK was 2,165,043 and this broke down into 1,789,586 in England,198,368 in Scotland,110,292 in Wales and 66,797 in Northern Ireland. The NHS is free at the time of use, for general practitioner and emergency treatment not including admission to hospital, people with the right to medical care in European Economic Area nations are also entitled to free treatment by using the European Health Insurance Card. Those from other countries with which the UK has reciprocal arrangements also qualify for free treatment, people not ordinarily resident in the UK are in general not entitled to free hospital treatment, with some exceptions such as refugees. People not ordinarily resident may be subject to an interview to establish their eligibility, patients who do not qualify for free treatment are asked to pay in advance, or to sign a written undertaking to pay, except for emergency treatment. The provision of treatment to non-UK-residents, formerly interpreted liberally, has been increasingly restricted. As of 2016 the surcharge was £200 per year, with exemptions and reductions in some cases, the systems are 98. 8% funded from general taxation and National Insurance contributions, plus small amounts from patient charges for some services
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Gauze
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Gauze is a thin, translucent fabric with a loose open weave. In technical terms gauze is a structure in which the weft yarns are arranged in pairs and are crossed before. This weave structure is used to add stability to fabric, which is important when using fine yarns loosely spaced, however, this weave structure can be used with any weight of yarn, and can be seen in some rustic textiles made from coarse hand-spun plant fiber yarns. Gauze was traditionally woven in Palestine and the English word is said to derive from the name for Gaza. Despite a prohibition on trade with non-Christians from religious authorities in medieval Europe, though members of religious orders in Europe were forbidden to wear it, the fabric won a place for itself and emerged into modern life as gauze. Gauze was originally made of silk and was used for clothing and it is now used for many different things, including gauze sponges for medical purposes. When used as a dressing, gauze is generally made of cotton. It is especially useful for dressing wounds where other fabrics might stick to the burn or laceration, many modern medical gauzes are covered with a plastic porous film such as Telfa or a polyblend which prevents direct contact and further minimizes wound adhesion. Also, it can be impregnated with a thick, creamy mixture of zinc oxide and calamine to promote healing, in film and theatre, gauze is often fashioned into a scrim. Gauze used in bookbinding is called mull, and is used in binding to adhere the text block to the book cover. Modern gauze is made of synthetic fibers, especially when used in clothing. It can also be made of metal, such as a wire gauze placed on top of a Bunsen burner, there are two types of wire gauze used in chemistry, a normally woven wire gauze, and one with a white circle imprinted on it. The latter has a ceramic composite intended to aid in the dispersal in heat, the normal set-up is a square stand to which a support ring is attached. The wire gauze is centered on the stand as to allow the open flame to be in contact with it to a certain extent. In the context of experimentation, the combination of the wire gauze plus the added ceramic composite greatly aids in the even dispersal of heat. This means that an object placed over this type of wire gauze will receive a more uniform heat from a Bunsen burner than the flame of it. Because of this desired heat dispersal ability, wire gauze can also be used as a surface for beakers, Erlenmeyers flasks or other vessels without damaging the supporting surface. Wire netting Mesh Adhesive bandage Lacebark Wire gauze Cotton gauze as non-adherent dressing at the Wayback Machine
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Tincture of iodine
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Tincture of iodine or iodine tincture is an antiseptic, it is also called weak iodine solution. It is usually 2–7% elemental iodine, along with potassium iodide or sodium iodide, dissolved in a mixture of ethanol, Tincture solutions are characterized by the presence of alcohol. It was used from 1908 in pre-operative skin preparation by surgeon Antonio Grossich. USP Tincture of Iodine is defined in the U. S. National Formulary as containing in each 100 mL,1.8 to 2.2 grams of elemental iodine, alcohol is 50 ml and the balance is purified water. This 2% free iodine solution provides about one mg of iodine per drop. USP Strong Iodine Tincture is defined in the NF as containing in each 100 mL,6.8 to 7.5 gram of iodine, purified water is 50 mL and the balance is alcohol. This 7% tincture solution is about 3.5 times more concentrated than USP 2% tincture, as in the case of Lugols iodine, the role of iodide in the solution is to increase the solubility of the elemental iodine, by turning it to the soluble triiodide anion I3−. However, since iodine has moderate solubility in ethanol, it is assisted by this solvent directly. Lugols iodine, by contrast, has no alcohol, and has twice the amount of iodide as elemental iodine, Tincture of iodine is often found in emergency survival kits, used both to disinfect wounds and to sanitize surface water for drinking. Small amounts may be added to drinking water as a disinfectant. Though this treatment is effective against bacteria and virus, it does not protect against protozoan parasites such as Cryptosporidium, Iodine solution is used to sanitize the surface of fruit and vegetables for bacteria and virus. The common concentration for sanitization is 25 ppm idophor for 1 minute, however, the effectiveness depends on whether the solution penetrates into rifts, and whether dirt is effectively removed at first. But, oocytes of protozoan parasites will not be killed, Iodine solutions should not be considered able to sanitize or disinfect salad, fruit or vegetables that are contaminated by feces. Thus, it should not be considered safe to eat raw fruit, salads and vegetables which are sanitized with iodine, Iodine tincture is not a recommended source of solely-nutritional iodine. Nutritional iodine is better supplied in the form of the less toxic iodide or iodate salts, application of tincture or Lugols to the skin also results in absorption and bioavailability of some moderate fraction of the iodine. Antiseptic Cadexomer iodine Chlorhexidine Iodophor Inadine Povidone-iodine Lugols iodine Brilliant Green Health Canada Drinking water quality See the section on, water away from home
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Chlorhexidine
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Chlorhexidine is a disinfectant and antiseptic that is used for skin disinfection before surgery and to sterilize surgical instruments. It may be used both to disinfect the skin of the patient and the hands of the healthcare providers and it is also used for cleaning wounds, preventing dental plaque, treating yeast infections of the mouth, and to keep urinary catheters from blocking. It is used as a liquid or powder, side effects may include skin irritation, teeth discoloration, and allergic reactions. May cause eye problems if direct contact occurs, use in pregnancy appears to be safe. Chlorhexidine may come mixed in alcohol, water, or surfactant solution and it is effective against a range of microorganisms though does not inactivate spores. Chlorhexidine came into use in the 1950s. It is on the World Health Organizations List of Essential Medicines, chlorhexidine is available over the counter. The wholesale cost in the world is about 2.20 to 4.10 USD per liter of 5% solution. In the United Kingdom this amount costs the NHS about £4.80, chlorhexidine is used in disinfectants, cosmetics, and pharmaceutical products. In endodontics chlorhexidine is used for root canal irrigation and as an intracanal dressing, there is tentative evidence that it is more effective than povidone-iodine. Chlorhexidine is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes and it is particularly effective against Gram-positive bacteria. Significantly higher concentrations are required for Gram-negative bacteria and fungi, chlorhexidine is ineffective against polioviruses and adenoviruses. The effectiveness against herpes viruses has not yet been established unequivocally, chlorhexidine, like other cation-active compounds, remains on the skin. It is frequently combined with alcohols, chlorhexidine is often used as an active ingredient in mouthwash designed to reduce dental plaque and oral bacteria. It has been shown to have a bactericidal action and a prolonged bacteriostatic action due to adsorption onto the pellicle-coated enamel surface. If it is not deactivated, chlorhexidine lasts longer in the mouth than other mouthwashes, to treat periodontal pockets equal or greater than 5 mm, chlorhexidine is also available in high concentration in a gelatin chip. These conditions included gingivitis, periodontitis, dental traumas, oral cysts, the clinical efficacy of the application of chlorhexidine as a component of oral rinses is well documented by many clinical studies summarized by review articles. The brownish discoloration of teeth and tongue is due to the disintegration of bacterial membranes, at the same time, disulfide functions are reduced to thiol functions that form dark complexes with iron ions found in saliva
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Gynecology
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Gynaecology or gynecology is the medical practice dealing with the health of the female reproductive systems and the breasts. Literally, outside medicine, the means the science of women. Its counterpart is andrology, which deals with issues specific to the male reproductive system. Almost all modern gynaecologists are also obstetricians, in many areas, the specialities of gynaecology and obstetrics overlap. The word gynaecology comes from the Greek γυνή, woman, and -logia, the Kahun Gynaecological Papyrus is the oldest known medical text of any kind. Dated to about 1800 BC, it deals with womens complaints—gynaecological diseases, fertility, pregnancy, contraception, the text is divided into thirty-four sections, each section dealing with a specific problem and containing diagnosis and treatment, no prognosis is suggested. Treatments are non surgical, comprising applying medicines to the body part or swallowing them. The womb is at times seen as the source of complaints manifesting themselves in other body parts, the Hippocratic Corpus contains several gynaecological treatises dating to the 5th/4th centuries BC. Aristotle is another source for medical texts from 4th century BC with his descriptions of biology primarily found in History of Animals, Parts of Animals. The gynaecological treatise Gynaikeia by Soranus of Ephesus is extant and he was the chief representative of the school of physicians known as the Methodists. J. Marion Sims is widely considered the father of modern gynaecology, Now criticized for the short comings. Now criticized for the short comings. He developed some of his techniques by operating on slaves, many of whom were not given anaesthesia, in some countries, women must first see a general practitioner prior to seeing a gynaecologist. If their condition requires training, knowledge, surgical procedure, or equipment unavailable to the GP, in the United States, however, law and many health insurance plans allow gynaecologists to provide primary care in addition to aspects of their own specialty. With this option available, some women opt to see a surgeon for non-gynaecological problems without another physicians referral. As in all of medicine, the tools of diagnosis are clinical history. Gynaecological examination is quite intimate, more so than a physical exam. It also requires unique instrumentation such as the speculum, Gynaecologists typically do a bimanual examination to palpate the cervix, uterus, ovaries and bony pelvis. It is not uncommon to do a rectovaginal examination for complete evaluation of the pelvis, male gynaecologists may have a female chaperone for their examination
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