The prime minister of Cambodia is the head of government of Cambodia. The prime minister is also the chairman of the Cabinet and leads the executive branch of the Royal Government of Cambodia. The prime minister is a member of parliament, and is appointed by the monarch for a term of five years. Since 1945, 37 individuals have served as prime minister; 33 as official prime ministers, and 4 in acting capacities. The current prime minister since 2023 is Hun Manet.

The politics of Cambodia are defined within the framework of a constitutional monarchy, in which the king serves as the head of state, and the prime minister is the head of government. The collapse of communism set in motion events that led to the withdrawal of the Vietnamese armed forces, which had established their presence in the country since the fall of the Khmer Rouge. The 1993 constitution, which is currently in force, was promulgated as a result of the 1991 Paris Peace Agreements, followed by elections organized under the aegis of the United Nations Transitional Authority in Cambodia. The constitution declares Cambodia to be an "independent, sovereign, peaceful, permanently neutral and non-aligned country." The constitution also proclaims a liberal, multiparty democracy in which powers are devolved to the executive, the judiciary and the legislature. However, there is no effective opposition to the Prime Minister Hun Sen, who has been in power from 1984 up to 2023. His Cambodian People's Party won all 125 seats in the National Assembly in 2018 after the banning of opposition party CNRP and KNLF. KNLF became a main opposition exiled in Denmark after CNRP was dissolved. During the communal election in 2022 and the national election in 2023, there were no international observers. The government is considered to be autocratic.