The Prince-Bishopric of Osnabrück was an ecclesiastical principality of the Holy Roman Empire from 1225 until 1803. It should not be confused with the Diocese of Osnabrück, which was larger and over which the prince-bishop exercised only the spiritual authority of an ordinary bishop. It was named after its capital, Osnabrück.

In the Holy Roman Empire, the German term Hochstift referred to the territory ruled by a bishop as a prince, as opposed to his diocese, generally much larger and over which he exercised only spiritual authority. The terms prince-bishopric and ecclesiastical principality are synonymous with Hochstift. Erzstift and Kurerzstift referred respectively to the territory (prince-archbishopric) ruled by a prince-archbishop and an elector-archbishop while Stift referred to the territory ruled by an imperial abbot or abbess, or a princely abbot or abbess. Stift was also often used to refer to any type of ecclesiastical principality.