The Princes in the Tower refers to the mystery of the fate of the deposed King Edward V of England and his younger brother Prince Richard of Shrewsbury, Duke of York, heirs to the throne of King Edward IV of England. The brothers were the only sons of the king by his queen, Elizabeth Woodville, living at the time of their father's death in 1483. Aged 12 and 9 years old, respectively, they were lodged in the Tower of London by their paternal uncle and England's regent, Richard, Duke of Gloucester, supposedly in preparation for Edward V's forthcoming coronation. Before the young king could be crowned, however, he and his brother were declared illegitimate. Gloucester ascended the throne as Richard III.

Perkin Warbeck was a pretender to the English throne claiming to be Richard of Shrewsbury, Duke of York, who was the second son of Edward IV and one of the so-called "Princes in the Tower". Richard, were he alive, would have been the rightful claimant to the throne, assuming that his elder brother Edward V was dead and that he was legitimate—a point that had been previously contested by his uncle, King Richard III.