Princess Amelia was the fifteenth and last child and sixth daughter of King George III of the United Kingdom and his wife, Charlotte of Mecklenburg-Strelitz. She was their third child to die before them.

Prince Octavius of Great Britain was the thirteenth child and eighth son of King George III and his queen consort, Charlotte of Mecklenburg-Strelitz. Six months after the death of his younger brother Prince Alfred, Octavius was inoculated against the smallpox virus. Several days later, he became ill. His subsequent death at the age of four devastated his parents, and in particular his father. King George III had been very fond of his two youngest sons, Alfred and Octavius, and his later bouts of madness involved hallucinations of them.