Priscilla Duffield worked on the Manhattan Project during World War II. She was secretary to Ernest O. Lawrence at the Radiation Laboratory, and to J. Robert Oppenheimer at the Los Alamos Laboratory. After the war she was executive assistant to directors of Scripps Institute of Oceanography and the National Accelerator Laboratory.

The Los Alamos Laboratory, also known as Project Y, was a secret laboratory established by the Manhattan Project and operated by the University of California during World War II. Its mission was to design and build the first atomic bombs. Robert Oppenheimer was its first director, serving from 1943 to December 1945, when he was succeeded by Norris Bradbury. In order to enable scientists to freely discuss their work while preserving security, the laboratory was located on the isolated Pajarito Plateau in Northern New Mexico. The wartime laboratory occupied buildings that had once been part of the Los Alamos Ranch School.