The Prophet's Mosque is the second mosque built by the Islamic prophet Muhammad in Medina, after that of Quba, as well as the second largest mosque and holiest site in Islam, after the Masjid al-Haram in Mecca, in the Saudi region of the Hejaz. The mosque is located at the heart of Medina, and is a major site of pilgrimage that falls under the purview of the Custodian of the Two Holy Mosques.

Mecca is the capital of Mecca Province in the Hejaz region of western Saudi Arabia and the holiest city in Islam. It is 70 km (43 mi) inland from Jeddah on the Red Sea, in a narrow valley 277 m (909 ft) above sea level. Its last recorded population was 2,385,509 in 2022. Its metropolitan population in 2022 is 2.4 million, making it the third-most populated city in Saudi Arabia after Riyadh and Jeddah. Around 44.5% of the population are Saudi citizens and around 55.5% are foreigners from other Muslim countries. Pilgrims more than triple the population number every year during the Ḥajj pilgrimage, observed in the twelfth Hijri month of Dhūl-Ḥijjah. With over 10.8 million international visitors in 2023, Mecca was one of the 10 most visited cities in the world.