The Prophet's Mosque is the second mosque built by the Islamic prophet Muhammad in Medina, after that of Quba, as well as the second largest mosque and holiest site in Islam, after the Masjid al-Haram in Mecca, in the Saudi region of the Hejaz. The mosque is located at the heart of Medina, and is a major site of pilgrimage that falls under the purview of the Custodian of the Two Holy Mosques.

Muḥammad ibn ʿAbd Allāh ibn ʿAbd al-Muṭṭalib is believed to be the Seal of the Prophets in all of the main branches of Islam. Muslims believe that the Quran, the central religious text of Islam, was revealed to Muhammad by God, and that Muhammad was sent to restore Islam, which they believe did not originate with Muhammad but is the true unaltered original monotheistic faith of Adam, Abraham, Moses, Jesus, and other prophets. The religious, social, and political tenets that Muhammad established with the Quran became the foundation of Islam and the Muslim world.