Protein targeting
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Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside the cell. Proteins can be targeted to the inner s
Günter Blobel, awarded the 1999 Nobel prize in Physiology for his discovery that proteins contain intrinsic signal sequences.
Endoplasmic reticulum
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The endoplasmic reticulum is a part of a transportation system of the eukaryotic cell, and has many other important functions such as protein folding. The word endoplasmic means "within the cytoplasm"
Protein targeting
…were translated by free ribosomes in the cytosol, while secreted proteins (and target proteins, in general) were translated by ribosomes bound to the endoplasmic reticulum (ER). Candidate explanations at the time postulated a processing difference between free and ER-bound ribosomes, but Blobel hypothesized that protein…
Ca2+-antagonized transport into the endoplasmic reticulum (CaATiER) model