The protohistoric period of the state of West Virginia in the United States began in the mid-sixteenth century with the arrival of European trade goods. Explorers and colonists brought these goods to the eastern and southern coasts of North America and were brought inland by native trade routes. This was a period characterized by increased intertribal strife, rapid population decline, the abandonment of traditional life styles, and the extinction and migrations of many Native American groups.

The Monongahela culture were an Iroquoian Native American cultural manifestation of Late Woodland peoples from AD 1050 to 1635 in present-day Western Pennsylvania, western Maryland, eastern Ohio, and West Virginia. The culture was named by Mary Butler in 1939 for the Monongahela River, whose valley contains the majority of this culture's sites.