Puerto Aysén is a city of Chile located in the Aysén del General Carlos Ibáñez del Campo Region, 4 kilometres (2 mi) above the head of Aisén Fjord in the country's extreme south. Puerto Aisén, which is the capital city of both the Aysén Province and the commune of Aisén is located 65 kilometres (40 mi) from the Regional Capital of Coyhaique, and 15 kilometres (9 mi) from the port of Puerto Chacabuco, main entry point to Puerto Aisén by sea. The main tourist attraction is Lagoon San Rafael.

The Aysén del General Carlos Ibáñez del Campo Region, often shortened to Aysén Region or Aisén, is one of Chile's 16 first order administrative divisions. Although the third largest in area, the region is Chile's most sparsely populated region with a population of 102,317 as of 2017. The capital of the region is Coyhaique, the region's former namesake. The region's current namesake is the former President of Chile, General Carlos Ibáñez del Campo.