Regeneration is a 1915 American silent biographical crime drama co-written and directed by Raoul Walsh. The film, which was the first full-length feature film directed by Walsh, stars Rockliffe Fellowes and Anna Q. Nilsson and was adapted for the screen by Carl Harbaugh and Walsh from the 1903 memoir My Mamie Rose, by Owen Frawley Kildare and the adapted 1908 play by Kildare and Walter C. Hackett.

Raoul Walsh was an American film director, actor, founding member of the Academy of Motion Picture Arts and Sciences (AMPAS), and the brother of silent screen actor George Walsh. He was known for portraying John Wilkes Booth in the silent film The Birth of a Nation (1915) and for directing such films as the widescreen epic The Big Trail (1930) starring John Wayne in his first leading role, The Roaring Twenties starring James Cagney and Humphrey Bogart, High Sierra (1941) starring Ida Lupino and Humphrey Bogart, and White Heat (1949) starring James Cagney and Edmond O'Brien. He directed his last film in 1964. His work has been noted as influences on directors such as Rainer Werner Fassbinder, Jack Hill, and Martin Scorsese.