Reggio di Calabria Centrale railway station is the main railway station of the Italian city of Reggio Calabria in Calabria. It is the most important station of its region and is owned by the Ferrovie dello Stato, the national rail company of Italy.

Reggio di Calabria, commonly and officially referred to as Reggio Calabria, or simply Reggio by its inhabitants, is the largest city in Calabria as well as the seat of the Regional Council of Calabria. It has an estimated population between 150,000 and 200,000 and is the twenty-first most populous city in Italy, after Modena and other Italian cities, and the 100th most populated city in Europe. Reggio Calabria is located near the center of the Mediterranean and is known for its climate, ethnic and cultural diversity. It is the third economic centre of mainland Southern Italy. About 560,000 people live in the metropolitan area, recognised in 2015 by Italy as a metropolitan city.