During the Holocaust, the Catholic Church played a role in the rescue of hundreds of thousands of Jews from being murdered by the Nazis. Members of the Church, through lobbying of Axis officials, provision of false documents, and the hiding of people in monasteries, convents, schools, among families and the institutions of the Vatican itself, saved hundreds of thousands of Jews. The Israeli diplomat and historian Pinchas Lapide estimated the figure at between 700,000 and 860,000, although the figure is contested.

Catholic resistance to Nazi Germany was a component of German resistance to Nazism and of Resistance during World War II. The role of the Catholic Church during the Nazi years remains a matter of much contention. From the outset of Nazi rule in 1933, issues emerged which brought the church into conflict with the regime and persecution of the church led Pope Pius XI to denounce the policies of the Nazi Government in the 1937 papal encyclical Mit brennender Sorge. His successor Pius XII faced the war years and provided intelligence to the Allies. Catholics fought on both sides in World War II and neither the Catholic nor Protestant churches as institutions were prepared to openly oppose the Nazi State.