The Revolt of the Brotherhoods was a revolt by artisan guilds (Germanies) against the government of King Charles V in the Kingdom of Valencia, part of the Crown of Aragon. It took place from 1519–1523, with most of the fighting occurring during 1521. The Valencian revolt inspired a related revolt in the island of Majorca, also part of Aragon, which lasted from 1521–1523.

Charles V was Holy Roman Emperor and Archduke of Austria from 1519 to 1556, King of Spain from 1516 to 1556, and Lord of the Netherlands as titular Duke of Burgundy from 1506 to 1555. He was heir to and then head of the rising House of Habsburg. His dominions in Europe included the Holy Roman Empire, extending from Germany to northern Italy with rule over the Austrian hereditary lands and Burgundian Low Countries, and Spain with its possessions of the southern Italian kingdoms of Naples, Sicily and Sardinia. In the Americas, he oversaw the continuation of Spanish colonization and a short-lived German colonization. The personal union of the European and American territories he ruled was the first collection of realms labelled "the empire on which the sun never sets".